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A Successful Liver Transplantation for Refractory Hepatic Veno-Occlusive Disease Originating from Cord Blood Transplantation
- Source :
- American Journal of Transplantation; September 2002, Vol. 2 Issue: 8 p796-800, 5p
- Publication Year :
- 2002
-
Abstract
- An 11-month-old boy with acute lymphoblastic leukemia (ALL) underwent umbilical cord blood transplantation (CBT) from an unrelated donor after a first complete remission. Despite the prophylactic use of low molecular weight heparin, prostaglandin E1 and ursodeoxycholic acid, hepatic veno-occlusive disease (VOD) occurred on the 29th day after CBT. Furthermore, neither defibrotide nor antithrombin-III improved the hepatic coma and coagulopathy due to the hepatic VOD. On the 42nd day after CBT, he underwent living related liver transplantation (LRLT) with a left lateral segment graft from his father. He received tacrolimus for the prevention of rejection and graft-vs.-host disease (GVHD) and also received aggressive antifungal and antiviral prophylaxis. Although he showed signs of acute rejection on postoperative days 5 and 10, the postoperative course was uneventful in general. At present, 17 months after LRLT, the patient shows stable liver function and no signs of either GVHD or a relapse of ALL. In conclusion, LRLT can be seen as a feasible option for the treatment of a hepatic VOD after CBT, though aggressive prophylaxis for infection and the anticipation of acute rejection are of importance.</BR>
Details
- Language :
- English
- ISSN :
- 16006135 and 16006143
- Volume :
- 2
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- American Journal of Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs4241295
- Full Text :
- https://doi.org/10.1034/j.1600-6143.2002.20815.x