Etude Preliminaire De La Reactivation Des Mecanismes Peripheriques Chez Les Schizophrenes*

The effect of mecholyl on peripheral reactivation was studied in schizophrenic patients under largactil or stemetil therapy and in schizophrenic patients without any tranquilizing pretreatment. Patients were further subdivided in “normoreactors” and “hyporeactors” according to Gellhorn classification based on the blood pressure response.In the group without any pretreatment mecholil causes a certain degree of sympathetic reactivation which is more intense in normoreactors. Both groups however did not show any positive sign of adrenocortical activation under such condition.Following pretreatment with largactil, both groups react by a somewhat lesser sympathetic reactivity; hyporeactors, however, show a certain degree of adrenocortical reactivation.Pretreatment with stemetil decreases still more the sympathetic reactions of both groups to mecholyl; the adrenocortical reactivation of normoreactors, under such conditions, appears to be greatly enhanced.