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Immunological Events during the Early Phase of Infection with Schistosoma Mansoniin Mice
- Source :
- International Journal of Immunopathology and Pharmacology; September 1997, Vol. 10 Issue: 3 p205-211, 7p
- Publication Year :
- 1997
-
Abstract
- Naturally occurring infection in humans or experimental infection in mice by Schistosoma mansonilead to a Th1 towards Th2 switch of cytokine response in the chronic late phase of the disease. It has been proposed that an initial Th1 response is successively down-regulated and followed by an egg-antigen driven Th2 response. Here we report the results of a kinetic study on the capacity of spleen cells from experimentally infected Balb/c mice to produce Th1 or Th2 cytokines, following mitogen stimulation, during the phase which precedes the granulomatous response associated to egg-deposition. The main results were identified as an early increase in IL-4 and IL-10 Th2 cytokine production, particularly pronounced for IL-10, only a slight and delayed decrease in IL-2 production and an invariable or actually enhanced capacity to produce IFN-γ. The emergence of Th2 response was associated with only slight and delayed modifications in spleen lymphocyte subsets, mainly represented by a decrease in CD3+ T cells and an increase in B cells. The initial unbalance of the Th1/Th2 response precedes thus the egg-deposition and the chronic phase of the infection, being evident 3 weeks after the challenge with the parasite. This observation could represent a novel finding useful in understanding the complex mechanisms involved in the immunopathogenesis of schistosomiasis.
Details
- Language :
- English
- ISSN :
- 03946320
- Volume :
- 10
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- International Journal of Immunopathology and Pharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs42198572
- Full Text :
- https://doi.org/10.1177/039463209701000306