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Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
Authors :
Shakur, Haleema Roberts, Ian Fawole, Bukola Chaudhri, Rizwana El-Sheikh, Mohamed Akintan, Adesina Qureshi, Zahida Kidanto, Hussein Vwalika, Bellington Abdulkadir, Abdulfetah Etuk, Saturday Noor, Shehla Asonganyi, Etienne Alfirevic, Zarko Beaumont, Danielle Ronsmans, Carine Arulkumaran, Sabaratnam Grant, Adrian Afsana, Kaosar Gülmezoglu, Metin Hunt, Beverley Olayemi, Oladapo Roberts, Ian Chalmers, Iain Lumbiganon, Pisake Piaggio, Gilda Brady, Tony Shakur, Haleema Roberts, Ian Alfirevic, Zarko Elbourne, Diana Gülmezoglu, Metin Ronsmans, Carine Balogun, Eni Pepple, Tracey Prowse, Danielle Quashi, Nigel Barneston, Lin Barrow, Collette Beaumont, Danielle Cook, Lisa Frimley, Lauren Gilbert, Daniel Gilliam, Catherine Jackson, Rob Kawahara, Taemi Miah, Hakim Kostrov, Sergey Ramos, Maria Roberts, Ian Shakur, Haleema Edwards, Phil Godec, Tom Huque, Sumaya Fawole, Bukola Okunade, Olujide Adetayo, Olusade Chaudhri, Rizwana Kayani, Aasia Javaid, Kiran Fawole, Bukola Chaudhri, Rizwana Biryabarema, Chrstine Qureshi, Zahida Tchounzou, Robert El-Sheikh, Mohamed Kidanto, Hussein Regmi, Mohan Vwalika, Bellington Dallaku, Kastriot Sahani, Mateus Akhter, Sayeba Abdulkadir, Abdulfetah Meda, Nicolas Dah, Anthony Kwame Akintan, Adesina Odekunle, Olufemi Monehin, Oluwabusola Ojo, Austin Akinbinu, Grace Offiah, Ifeoma Etuk, Saturday Akpan, Ubong Udofia, Uduak Okon, Useneno Omoronyia, Ezukwa James, Okpe Olayemi, Oladapo Bello, Nike Adeyemi, Blessed Aimakhu, Chris Akinsanya, Olufemi Adeleye, Bamidele Adeyemi, Oluwaseun Oluwatosin, Kayode Aboyeji, Abiodun Adeniran, Abiodun Adewale, Adebayo Olaomo, Noah Omo-Aghoja, Lawrence Okpako, Emmanuel Oyeye, Lucky Alu, Francis Ogudu, John Ladan, Ezekiel Habib, Ibrahim Okusanya, Babasola Onafowokan, Olatunde Isah, David Aye, Abalaka Okogbo, Felix Aigere, Egbaname Ogbiti, Mark Onile, Temitope Salau, Olaide Amode, Yinka Shoretire, Kamil Owodunni, Adebola Ologunde, Kehinde Ayinde, Akintunde Alao, Moses Awonuga, Olalekan Awolaja, Babatunde Adegbola, Omololu Habeebu-Adeyemi, Fatimah Okunowo, Adeyemi Idris, Hadiza Okike, Ola Madueke, Nneka Mutihir, Josiah Joseph, Nankat Adebudo, Babatunde Fasanu, Adeniyi Akintunde, Olugbenga Abidoye, Olufemi Opreh, Owigho Udonwa, Sophia Dibia, Gladys Bazuaye, Simeon Ifemeje, Arafat Umoiyoho, Aniefiok Inyang-Etoh, Emmanuel Yusuf, Sununu Olayinka, Kayode Adeyemi, Babalola Ajenifuja, Olusegun Ibrahim, Umar Adamu, Yusuf Baffah Akinola, Oluwarotimi Adekola-Oni, Grace Kua, Paul Iheagwam, Roseline Idrisa, Audu Geidam, Ado Jogo, Andrea Agulebe, Joseph Ikechebelu, Joseph Udegbunam, Onyebuchi Awoleke, Jacob Adelekan, Oluseyi Sulayman, Hajaratu Ameh, Nkeiruka Onaolapo, Nurudeen Adelodun, Affiss Golit, William Audu, Dachollom Adeniji, Adetunji Oyelade, Folasade Dattijo, Lamaran Henry, Palmer Adeyemi, Babalola Loto, Olabisi Umeora, Odidika Onwe, Abraham Nzeribe, Emily Okorochukwu, Bartthy Adeniyi, Augustine Gbejegbe, Emmanuel Ikpen, Akpojaro Nwosu, Ikemefuna Sambo, Abdulrasaq Ladipo, Olubunmi Abubakar, Sola Okike, Ola Nene Nduka, Enyinnaya Chikwendu Ezenkwele, Eziamaka Pauline Onwusulu, Daniel Irinyenikan, Theresa Azonima Singh, Swati Bariweni, Amaitari Galadanci, Hadiza Achara, Peter Osayande, Osagie Gana, Mohammed Chaudhri, Rizwana Jabeen, Kiran Mobeen, Ayesha Mufti, Sadaf Zafar, Maliha Noor, Shehla Ahmad, Basharat Munawar, Maimoona Gul, Jeharat Usman, Naseema Shaheen, Fehmida Tariq, Mariam Sadiq, Nadia Batool, Rabia Ali, Habiba Sharaf Jaffer, Manahil Baloch, Asma Mukhtiar, Noonari Ashraf, Tasneem Asmat, Raheela Khudaidad, Salma Taj, Ghazala Qazi, Roshan Dars, Saira Sardar, Faryal Ashfaq, Sanobar Majeed, Saeeda Jabeen, Sadaqat Karim, Rukhsana Burki, Farzana Bukhari, Syeda Rabia Gul, Fouzia Jabeen, Musarrat Sherin, Akhtar Ain, Qurratul Rao, Shahid Shaheen, Uzma Manzoor, Samina Masood, Shabween Rizvi, Shabana Ali, Anita Sajid, Abida Iftikhar, Aisha Batool, Shazia Dar, Lubna Sohail, Shahenzad Rasul, Shazia Humayun, Shamsa Sultana, Rashida Manzoor, Sofia Mazhar, Syeda Batool, Afshan Nazir, Asia Tasnim, Nasira Masood, Hajira Khero, Razia Surhio, Neelam Aleem, Samana Israr, Naila Javed, Saba Bashir, Lubna Iqbal, Samina Aleem, Faiza Sohail, Rubina Iqbal, Saima Dojki, Samina Bano, Alia Saba, Naseem Hafeez, Maimoona Akram, Nishat Israr, Naila Shaheen, Riffat Hashmi, Haleema Arshad, Sharmeen Hussain, Rubina Khan, Sadia Shaheen, Nighat Khalil, Safia Sachdev, Pushpa Arain, Gulfareen Zarreen, Amtullah Saeed, Sara Hanif, Shamayela Tariq, Nabia Jamil, Mahwish Chaudhry, Shama Rajani, Hina Wasim, Tayyiba Aslam, Summera Mustafa, Nilofar Quddusi, Huma Karim, Sajila Sultana, Shazia Harim, Misbah Chohan, Mohd Salman, Nabila Waqar, Fareesa Sadia, Shamsunnisa Kahloon, Lubna Manzoor, Shehla Amin, Samar Akram, Umbreen Ikram, Ambreen Kausar, Samina Batool, Tahira Naila, Brigadier Kyani, Tahir Biryabarema, Christine Bulime, Ruth Akello, Regina Lwasa, Bernadette Nakawooya Ayikoru, Joselyn Namulwasira, Christine Komagum, Patrick Rebecca, Isabirye Annet, Nayiga Nuulu, Nakirigya Nionzima, Elizabeth Bwotya, Rose Nankya, Margret Babirye, Sarah Ngonzi, Joseph Sanchez, Cesar Innocent, Nkonwa Anitah, Kusasira Jackson, Ayiko Ndagire, Elizabeth Nanyongo, Christine Drametu, Dominic Meregurwa, Grace Banya, Francis Atim, Rita Byaruhanga, Emmanuel Felix, Lema Iman, Hussein Oyiengo, Vincent Waigi, Peninah Wangui, Rose Nassir, Faiza Soita, Musimbi Msengeti, Rophina Zubier, Zeinab Mabeya, Hillary Wanjala, Antony Mwangi, Henry Liyayi, Brian Muthoka, Evelyn Osoti, Alfred Otara, Amos Ongwae, Veronicah Qureshi, Zahida Wanjohi, Victor Musila, Bonface Wekesa, Kubasu Bosire, Alex Nyakundi Asonganyi, Etienne Ntem, Alice Njoache, Angeline Ashu, Alice Simo, André Tchounzou, Robert Keka, Dorothy Bruno, Kenfack Ndouoya, Amadou Saadio, Martin Tchana, Mesack Gwan, Odel Assomo, Pauline Mutsu, Venantius Eric, Nji Foumane, Pascal Nsem, Philemon Fouedjio, Jeanne Fouelifack, Ymele Tebeu, Pierre Marie Nko'ayissi, Georges Mbong, Eta Ngole Nabag, Wisal Desougi, Riham Mustafa, Hadia Eltaib, Huida Umbeli, Taha Elfadl, Khalid Ibrahim, Murwan Mohammed, Abdalla Ali, Awadia Abdelrahiem, Somia Musa, Mohammed Awadalla, Khidir Ahmed, Samirra Bushra, Mahdi Babiker, Omer Abdullahi, Hala Ahmed, Mohamed Safa, Elhassan Almardi, Huida Rayis, Duria Abdelgabar, Saeed Abdelrahman Alfirevic, Zarko Houghton, Gillian Sharpe, Andrew Thornton, Jim Grace, Nick Smith, Carys Hinshaw, Kim Edmundson, Dawn Ayuk, Paul Bates, Alison Bugg, George Wilkins, Joanne Tower, Clare Allibone, Alysha Oteng-Ntim, Eugene Kidanto, Hussein Kazumari, Ahmad Danford, Anna Ngarina, Matilda Abeid, Muzdalifat Mayumba, Khadija Zacharia, Magreth Mtove, George Madame, Leonard Massinde, Anthony Mwambe, Berno Onesmo, Rwakyendela Ganyaka, Sebastian Kitengile Regmi, Mohan Gupta, Shyam Bhatt, Rabindra Agrawal, Ajay Pradhan, Pramila Dhakal, Nikita Yadav, Punita Karki, Gyanendra Shrestha, Bhola Ram Vwalika, Bellington Lubeya, Mwansa Mumba, Jane Silwimba, Willies Hansingo, Isaiah Bopili, Noojiri Makukula, Ziche Kawimbe, Alexander Lubeya, Mwansa Ketty Mtambo, Willard Ng'ambi, Mathew Dallaku, Kastriot Cenameri, Saimir Tasha, Ilir Kruja, Aferdita Brahimaj, Besnik Tola, Armida Kaza, Leon Sahani, Mateus Tshombe, Desire Buligho, Elizabeth Paluku-Hamuli, Roger Kacha, Charles Faida, Kato Musau, Badibanga Kalyana, Herman Simisi, Phanny Mulyumba, Serge Jason, Nzanzu Kikuhe Lubamba, Jean Robert Missumba, Willis Islam, Ferdousi Begum, Nazneen Akhter, Sayeba Chowdhury, Ferdousi Begum, Rokeya Basher, Farjana Nargis, Nazlima Kholdun, Abu Jesmin, Shahela Paul, Shrodha Segni, Hailemariam Ayana, Getachew Haleke, William Abdulkadir, Abdulfetah Hussien, Hassen Geremew, Fikre Bambara, Moussa Somé, Adolphe Ly, Amadou Pabakba, Roamba Fletcher, Horace Samuels, Leslie Opare-Addo, Henry Larsen-Reindorf, Roderick Nyarko-Jectey, Kwadwo Mola, Glen Wai, Malts El Rahman, Magdy Basta, Wafaa Khamis, Hussein Escobar, Maria Fernanda Vallecilla, Liliana Faye, Gabriel Essetchi
Source :
The Lancet; May-June 2017, Vol. 389 Issue: 10084 p2105-2116, 12p
Publication Year :
2017
Abstract
Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
389
Issue :
10084
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs41885974
Full Text :
https://doi.org/10.1016/S0140-6736(17)30638-4