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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Authors :
Phelan, Catherine M Kuchenbaecker, Karoline B Tyrer, Jonathan P Kar, Siddhartha P Lawrenson, Kate Winham, Stacey J Dennis, Joe Pirie, Ailith Riggan, Marjorie J Chornokur, Ganna Earp, Madalene A Lyra, Paulo C Lee, Janet M Coetzee, Simon Beesley, Jonathan McGuffog, Lesley Soucy, Penny Dicks, Ed Lee, Andrew Barrowdale, Daniel Lecarpentier, Julie Leslie, Goska Aalfs, Cora M Aben, Katja K H Adams, Marcia Adlard, Julian Andrulis, Irene L Anton-Culver, Hoda Antonenkova, Natalia Aravantinos, Gerasimos Arnold, Norbert Arun, Banu K Arver, Brita Azzollini, Jacopo Balmaña, Judith Banerjee, Susana N Barjhoux, Laure Barkardottir, Rosa B Bean, Yukie Beckmann, Matthias W Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina Bernardini, Marcus Q Birrer, Michael J Bjorge, Line Black, Amanda Blankstein, Kenneth Blok, Marinus J Bodelon, Clara Bogdanova, Natalia Bojesen, Anders Bonanni, Bernardo Borg, Åke Bradbury, Angela R Brenton, James D Brewer, Carole Brinton, Louise Broberg, Per Brooks-Wilson, Angela Bruinsma, Fiona Brunet, Joan Buecher, Bruno Butzow, Ralf Buys, Saundra S Caldes, Trinidad Caligo, Maria A Campbell, Ian Cannioto, Rikki Carney, Michael E Cescon, Terence Chan, Salina B Chang-Claude, Jenny Chanock, Stephen Chen, Xiao Qing Chiew, Yoke-Eng Chiquette, Jocelyne Chung, Wendy K Claes, Kathleen B M Conner, Thomas Cook, Linda S Cook, Jackie Cramer, Daniel W Cunningham, Julie M D'Aloisio, Aimee A Daly, Mary B Damiola, Francesca Damirovna, Sakaeva Dina Dansonka-Mieszkowska, Agnieszka Dao, Fanny Davidson, Rosemarie DeFazio, Anna Delnatte, Capucine Doheny, Kimberly F Diez, Orland Ding, Yuan Chun Doherty, Jennifer Anne Domchek, Susan M Dorfling, Cecilia M Dörk, Thilo Dossus, Laure Duran, Mercedes Dürst, Matthias Dworniczak, Bernd Eccles, Diana Edwards, Todd Eeles, Ros Eilber, Ursula Ejlertsen, Bent Ekici, Arif B Ellis, Steve Elvira, Mingajeva Eng, Kevin H Engel, Christoph Evans, D Gareth Fasching, Peter A Ferguson, Sarah Ferrer, Sandra Fert Flanagan, James M Fogarty, Zachary C Fortner, Renée T Fostira, Florentia Foulkes, William D Fountzilas, George Fridley, Brooke L Friebel, Tara M Friedman, Eitan Frost, Debra Ganz, Patricia A Garber, Judy García, María J Garcia-Barberan, Vanesa Gehrig, Andrea Gentry-Maharaj, Aleksandra Gerdes, Anne-Marie Giles, Graham G Glasspool, Rosalind Glendon, Gord Godwin, Andrew K Goldgar, David E Goranova, Teodora Gore, Martin Greene, Mark H Gronwald, Jacek Gruber, Stephen Hahnen, Eric Haiman, Christopher A Håkansson, Niclas Hamann, Ute Hansen, Thomas V O Harrington, Patricia A Harris, Holly R Hauke, Jan Hein, Alexander Henderson, Alex Hildebrandt, Michelle A T Hillemanns, Peter Hodgson, Shirley Høgdall, Claus K Høgdall, Estrid Hogervorst, Frans B L Holland, Helene Hooning, Maartje J Hosking, Karen Huang, Ruea-Yea Hulick, Peter J Hung, Jillian Hunter, David J Huntsman, David G Huzarski, Tomasz Imyanitov, Evgeny N Isaacs, Claudine Iversen, Edwin S Izatt, Louise Izquierdo, Angel Jakubowska, Anna James, Paul Janavicius, Ramunas Jernetz, Mats Jensen, Allan Jensen, Uffe Birk John, Esther M Johnatty, Sharon Jones, Michael E Kannisto, Päivi Karlan, Beth Y Karnezis, Anthony Kast, Karin Kennedy, Catherine J Khusnutdinova, Elza Kiemeney, Lambertus A Kiiski, Johanna I Kim, Sung-Won Kjaer, Susanne K Köbel, Martin Kopperud, Reidun K Kruse, Torben A Kupryjanczyk, Jolanta Kwong, Ava Laitman, Yael Lambrechts, Diether Larrañaga, Nerea Larson, Melissa C Lazaro, Conxi Le, Nhu D Le Marchand, Loic Lee, Jong Won Lele, Shashikant B Leminen, Arto Leroux, Dominique Lester, Jenny Lesueur, Fabienne Levine, Douglas A Liang, Dong Liebrich, Clemens Lilyquist, Jenna Lipworth, Loren Lissowska, Jolanta Lu, Karen H Lubinński, Jan Luccarini, Craig Lundvall, Lene Mai, Phuong L Mendoza-Fandiño, Gustavo Manoukian, Siranoush Massuger, Leon F A G May, Taymaa Mazoyer, Sylvie McAlpine, Jessica N McGuire, Valerie McLaughlin, John R McNeish, Iain Meijers-Heijboer, Hanne Meindl, Alfons Menon, Usha Mensenkamp, Arjen R Merritt, Melissa A Milne, Roger L Mitchell, Gillian Modugno, Francesmary Moes-Sosnowska, Joanna Moffitt, Melissa Montagna, Marco Moysich, Kirsten B Mulligan, Anna Marie Musinsky, Jacob Nathanson, Katherine L Nedergaard, Lotte Ness, Roberta B Neuhausen, Susan L Nevanlinna, Heli Niederacher, Dieter Nussbaum, Robert L Odunsi, Kunle Olah, Edith Olopade, Olufunmilayo I Olsson, Håkan Olswold, Curtis O'Malley, David M Ong, Kai-ren Onland-Moret, N Charlotte Orr, Nicholas Orsulic, Sandra Osorio, Ana Palli, Domenico Papi, Laura Park-Simon, Tjoung-Won Paul, James Pearce, Celeste L Pedersen, Inge Søkilde Peeters, Petra H M Peissel, Bernard Peixoto, Ana Pejovic, Tanja Pelttari, Liisa M Permuth, Jennifer B Peterlongo, Paolo Pezzani, Lidia Pfeiler, Georg Phillips, Kelly-Anne Piedmonte, Marion Pike, Malcolm C Piskorz, Anna M Poblete, Samantha R Pocza, Timea Poole, Elizabeth M Poppe, Bruce Porteous, Mary E Prieur, Fabienne Prokofyeva, Darya Pugh, Elizabeth Pujana, Miquel Angel Pujol, Pascal Radice, Paolo Rantala, Johanna Rappaport-Fuerhauser, Christine Rennert, Gad Rhiem, Kerstin Rice, Patricia Richardson, Andrea Robson, Mark Rodriguez, Gustavo C Rodríguez-Antona, Cristina Romm, Jane Rookus, Matti A Rossing, Mary Anne Rothstein, Joseph H Rudolph, Anja Runnebaum, Ingo B Salvesen, Helga B Sandler, Dale P Schoemaker, Minouk J Senter, Leigha Setiawan, V Wendy Severi, Gianluca Sharma, Priyanka Shelford, Tameka Siddiqui, Nadeem Side, Lucy E Sieh, Weiva Singer, Christian F Sobol, Hagay Song, Honglin Southey, Melissa C Spurdle, Amanda B Stadler, Zsofia Steinemann, Doris Stoppa-Lyonnet, Dominique Sucheston-Campbell, Lara E Sukiennicki, Grzegorz Sutphen, Rebecca Sutter, Christian Swerdlow, Anthony J Szabo, Csilla I Szafron, Lukasz Tan, Yen Y Taylor, Jack A Tea, Muy-Kheng Teixeira, Manuel R Teo, Soo-Hwang Terry, Kathryn L Thompson, Pamela J Thomsen, Liv Cecilie Vestrheim Thull, Darcy L Tihomirova, Laima Tinker, Anna V Tischkowitz, Marc Tognazzo, Silvia Toland, Amanda Ewart Tone, Alicia Trabert, Britton Travis, Ruth C Trichopoulou, Antonia Tung, Nadine Tworoger, Shelley S van Altena, Anne M Van Den Berg, David van der Hout, Annemarie H van der Luijt, Rob B Van Heetvelde, Mattias Van Nieuwenhuysen, Els van Rensburg, Elizabeth J Vanderstichele, Adriaan Varon-Mateeva, Raymonda Vega, Ana Edwards, Digna Velez Vergote, Ignace Vierkant, Robert A Vijai, Joseph Vratimos, Athanassios Walker, Lisa Walsh, Christine Wand, Dorothea Wang-Gohrke, Shan Wappenschmidt, Barbara Webb, Penelope M Weinberg, Clarice R Weitzel, Jeffrey N Wentzensen, Nicolas Whittemore, Alice S Wijnen, Juul T Wilkens, Lynne R Wolk, Alicja Woo, Michelle Wu, Xifeng Wu, Anna H Yang, Hannah Yannoukakos, Drakoulis Ziogas, Argyrios Zorn, Kristin K Narod, Steven A Easton, Douglas F Amos, Christopher I Schildkraut, Joellen M Ramus, Susan J Ottini, Laura Goodman, Marc T Park, Sue K Kelemen, Linda E Risch, Harvey A Thomassen, Mads Offit, Kenneth Simard, Jacques Schmutzler, Rita Katharina Hazelett, Dennis Monteiro, Alvaro N Couch, Fergus J Berchuck, Andrew Chenevix-Trench, Georgia Goode, Ellen L Sellers, Thomas A Gayther, Simon A Antoniou, Antonis C Pharoah, Paul D P
Source :
Nature Genetics; May 2017, Vol. 49 Issue: 5 p680-691, 12p
Publication Year :
2017
Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Details
Language :
English
ISSN :
10614036 and 15461718
Volume :
49
Issue :
5
Database :
Supplemental Index
Journal :
Nature Genetics
Publication Type :
Periodical
Accession number :
ejs41803663
Full Text :
https://doi.org/10.1038/ng.3826