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Impact of Preferentially Expressed Antigen of Melanoma on the Prognosis of Hepatocellular Carcinoma
- Source :
- Gastrointestinal Tumors; March 2017, Vol. 3 Issue: 3-4 p128-135, 8p
- Publication Year :
- 2017
-
Abstract
- Background:Retinoids, vitamin A and its derivatives, have an antitumor effect on hepatocellular carcinoma (HCC). The function of retinoids is exerted by the complex of retinoic acid (RA) with the heterodimer of retinoid X receptor and the RA receptor. The preferentially expressed antigen of melanoma (PRAME) acts as a dominant repressor of RA signaling by binding to the complex. The significance of PRAME on the prognosis of HCC remains to be clarified. Methods:PRAME mRNA expression was examined by quantitative real-time polymerase chain reaction in both tumor and non-tumor tissues of 100 HCC patients who received surgical resection. The effect of PRAME knockdown on DR5-mediated RA transcriptional activity was examined. Results:In tumor tissues, there were significant associations among PRAME expression, clinical stage, tumor markers, and tumor numbers. In non-tumor tissues, there were significant associations among PRAME expression, overall survival, and disease-free survival. The knockdown of PRAME caused no reduction in DR5-mediated transcriptional activity of RA, suggesting that PRAME acts via other mechanisms than the DR5 RA-responsive elements. Conclusion:Our findings indicate that PRAME expression is a novel prognostic marker in HCC patients.
Details
- Language :
- English
- ISSN :
- 22963774 and 22963766
- Volume :
- 3
- Issue :
- 3-4
- Database :
- Supplemental Index
- Journal :
- Gastrointestinal Tumors
- Publication Type :
- Periodical
- Accession number :
- ejs41543736
- Full Text :
- https://doi.org/10.1159/000448137