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Delayed differentiation of potent effector CD8+T cells reducing viremia and reservoir seeding in acute HIV infection

Authors :
Takata, Hiroshi
Buranapraditkun, Supranee
Kessing, Cari
Fletcher, James L. K.
Muir, Roshell
Tardif, Virginie
Cartwright, Pearline
Vandergeeten, Claire
Bakeman, Wendy
Nichols, Carmen N.
Pinyakorn, Suteeraporn
Hansasuta, Pokrath
Kroon, Eugene
Chalermchai, Thep
O’Connell, Robert
Kim, Jerome
Phanuphak, Nittaya
Robb, Merlin L.
Michael, Nelson L.
Chomont, Nicolas
Haddad, Elias K.
Ananworanich, Jintanat
Trautmann, Lydie
Source :
Science Translational Medicine; February 2017, Vol. 9 Issue: 377
Publication Year :
2017

Abstract

Potent CD8+T cells endowed with effector functions able to kill HIV-producing cells and reduce the seeding of the HIV reservoir are only detected at peak viremia in acute HIV infection.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
9
Issue :
377
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs41349956
Full Text :
https://doi.org/10.1126/scitranslmed.aag1809