Back to Search
Start Over
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
- Source :
- Science Signaling; February 2017, Vol. 10 Issue: 466
- Publication Year :
- 2017
-
Abstract
- Acetylation of MDM2 promotes its oncogenic function by blocking its self-ubiquitination while enhancing its ubiquitination of the tumor suppressor p53.
Details
- Language :
- English
- ISSN :
- 19450877 and 19379145
- Volume :
- 10
- Issue :
- 466
- Database :
- Supplemental Index
- Journal :
- Science Signaling
- Publication Type :
- Periodical
- Accession number :
- ejs41349947
- Full Text :
- https://doi.org/10.1126/scisignal.aai8026