Anti-AIDS Agents. 48.<SUP>1</SUP> Anti-HIV Activity of Moronic Acid Derivatives and the New Melliferone-Related Triterpenoid Isolated from Brazilian Propolis

Authors :: Ito, J.
Chang, F.-R.
Wang, H.-K.
Park, Y. K.
Ikegaki, M.
Kilgore, N.
Lee, K.-H.
Source :: Journal of Natural Products; October 26, 2001, Vol. 64 Issue: 10 p1278-1281, 4p
Publication Year :: 2001
Abstract: A new triterpenoid named melliferone (<BO>1</BO>), three known triterpenoids, moronic acid (<BO>2</BO>), anwuweizonic acid (<BO>3</BO>), and betulonic acid (<BO>4</BO>), and four known aromatic compounds (<BO>5</BO>−<BO>8</BO>) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (<BO>2</BO>) showed significant anti-HIV activity (EC<INF>50</INF> &lt;0.1 μg/mL, TI >186) and was modified to develop more potent anti-AIDS agents.

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