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Complete attenuation of genetically engineered Plasmodium falciparumsporozoites in human subjects

Authors :
Kublin, James G.
Mikolajczak, Sebastian A.
Sack, Brandon K.
Fishbaugher, Matt E.
Seilie, Annette
Shelton, Lisa
VonGoedert, Tracie
Firat, Melike
Magee, Sara
Fritzen, Emma
Betz, Will
Kain, Heather S.
Dankwa, Dorender A.
Steel, Ryan W. J.
Vaughan, Ashley M.
Noah Sather, D.
Murphy, Sean C.
Kappe, Stefan H. I.
Source :
Science Translational Medicine; January 2017, Vol. 9 Issue: 371
Publication Year :
2017

Abstract

A genetically attenuated Plasmodium falciparumstrain called Pf GAP3KO is completely attenuated, safe, and immunogenic in adults.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
9
Issue :
371
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs41120101
Full Text :
https://doi.org/10.1126/scitranslmed.aad9099