Germline mutations in PTENand SDHCin a woman with epithelial thyroid cancer and carotid paraganglioma

Germline mutations inPTENresult in the uncommon Cowden Syndrome. Heterozygous mutations of SDH B, Cand Dare associated with the hereditary pheochromocytoma–paraganglioma syndrome. Zbuk et al. present the first-reported case of a woman with both PTENand SDHCmutations, which resulted in multiple neoplasias. The authors highlight the need for predictive genetic tests and close clinical surveillance of patients with suspected Cowden or pheochromocytoma–paraganglioma syndromes.