Prospective, observational study of antiplatelet and coagulation biomarkers as predictors of thromboembolic events after implantation of ventricular assist devices

Ventricular assist devices (VADs) are associated with thromboembolic events. Aspirin hyporesponsiveness has been associated with an increased risk of future vascular atherothrombotic events, such as acute coronary syndromes and cerebrovascular accidents, but whether this disorder can predict future clinical thromboembolic events in patients with VADs remains unclear. In this article, the prevalence and clinical relevance of aspirin hyporesponsiveness before and after VAD implantation and the role of markers of coagulation and fibrinolysis were assessed.