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The SCFβ-TRCPE3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Authors :
Shimizu, Kouhei
Fukushima, Hidefumi
Ogura, Kohei
Lien, Evan C.
Nihira, Naoe Taira
Zhang, Jinfang
North, Brian J.
Guo, Ailan
Nagashima, Katsuyuki
Nakagawa, Tadashi
Hoshikawa, Seira
Watahiki, Asami
Okabe, Koji
Yamada, Aya
Toker, Alex
Asara, John M.
Fukumoto, Satoshi
Nakayama, Keiichi I.
Nakayama, Keiko
Inuzuka, Hiroyuki
Wei, Wenyi
Source :
Science Signaling; January 2017, Vol. 10 Issue: 460
Publication Year :
2017

Abstract

The targeting of Lipin1 by the SCFβ-TRCPE3 ubiquitin ligase complex enhances lipid synthesis and accumulation in the liver.

Details

Language :
English
ISSN :
19450877 and 19379145
Volume :
10
Issue :
460
Database :
Supplemental Index
Journal :
Science Signaling
Publication Type :
Periodical
Accession number :
ejs41033752
Full Text :
https://doi.org/10.1126/scisignal.aah4117