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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Authors :
Goodship, Timothy H.J.
Cook, H. Terence
Fakhouri, Fadi
Fervenza, Fernando C.
Frémeaux-Bacchi, Véronique
Kavanagh, David
Nester, Carla M.
Noris, Marina
Pickering, Matthew C.
Rodríguez de Córdoba, Santiago
Roumenina, Lubka T.
Sethi, Sanjeev
Smith, Richard J.H.
Alpers, Charlie E.
Appel, Gerald B.
Ardissino, Gianluigi
Ariceta, Gema
Arici, Mustafa
Bagga, Arvind
Bajema, Ingeborg M.
Blasco, Miguel
Burke, Linda
Cairns, Thomas D.
Carratala, Mireya
D'Agati, Vivette D.
Daha, Mohamed R.
De Vriese, An S.
Dragon-Durey, Marie-Agnès
Fogo, Agnes B.
Galbusera, Miriam
Gale, Daniel P.
Haller, Hermann
Johnson, Sally
Józsi, Mihály
Karpman, Diana
Lanning, Lynne
Le Quintrec, Moglie
Licht, Christoph
Loirat, Chantal
Monfort, Francisco
Morgan, B. Paul
Noël, Laure-Hélène
O'Shaughnessy, Michelle M.
Rabant, Marion
Rondeau, Eric
Ruggenenti, Piero
Sheerin, Neil S.
Smith, Jenna
Spoleti, Fabrizio
Thurman, Joshua M.
van de Kar, Nicole C.A.J.
Vivarelli, Marina
Zipfel, Peter F.
Source :
Kidney International; March 2017, Vol. 91 Issue: 3 p539-551, 13p
Publication Year :
2017

Abstract

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.

Details

Language :
English
ISSN :
00852538 and 15231755
Volume :
91
Issue :
3
Database :
Supplemental Index
Journal :
Kidney International
Publication Type :
Periodical
Accession number :
ejs40761743
Full Text :
https://doi.org/10.1016/j.kint.2016.10.005