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Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Authors :
Thorek, Daniel L. J.
Watson, Philip A.
Lee, Sang-Gyu
Ku, Anson T.
Bournazos, Stylianos
Braun, Katharina
Kim, Kwanghee
Sjöström, Kjell
Doran, Michael G.
Lamminmäki, Urpo
Santos, Elmer
Veach, Darren
Turkekul, Mesruh
Casey, Emily
Lewis, Jason S.
Abou, Diane S.
van Voss, Marise R. H.
Scardino, Peter T.
Strand, Sven-Erik
Alpaugh, Mary L.
Scher, Howard I.
Lilja, Hans
Larson, Steven M.
Ulmert, David
Source :
Science Translational Medicine; November 2016, Vol. 8 Issue: 367 p367ra167-367ra167, 1p
Publication Year :
2016

Abstract

A radiolabeled antibody against a secreted antigen uses Fc receptor–mediated internalization for cancer imaging and therapy.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
8
Issue :
367
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs40584415
Full Text :
https://doi.org/10.1126/scitranslmed.aaf2335