Increased Analgesia to Thermal Stimuli in Rats after Brief Exposures to Complex Pulsed 1 Microtesla Magnetic Fields

Nociceptive thresholds to a 55°C hot surface were measured for female Wistar rats before treatments and 30 min. and 60 min. after the treatments. After injection with either naloxone or saline following baseline measurements, the rats were exposed for 30 min. to either sham fields or to weak (about 1 microTesla) burst-firing magnetic fields composed of 230 points (4 msec. per point) presented once every 3 sec. The rats that had received the burst-firing magnetic fields exhibited elevated nociceptive thresholds that explained about 50% of the variance. A second pattern, designed after the behaviour of individual thalamic neurons during nociceptive input and called the “activity rhythm magnetic field” produced only a transient analgesic effect. These results replicated previous studies and Suggest that weak, extremely low frequency, pulsed magnetic fields with biorelevant temporal structures may have utility as adjuncts for treatment of pain.