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Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy
- Source :
- Nature Structural and Molecular Biology; October 2016, Vol. 23 Issue: 10 p899-905, 7p
- Publication Year :
- 2016
-
Abstract
- Cryo-EM and mass spectrometry analyses of the spike glycoprotein trimer from coronavirus HcoV-NL63 reveal an extensive glycan shield that covers the protein surface, including an epitope targeted by neutralizing antibodies against several coronaviruses.
Details
- Language :
- English
- ISSN :
- 15459993 and 15459985
- Volume :
- 23
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Nature Structural and Molecular Biology
- Publication Type :
- Periodical
- Accession number :
- ejs40136539
- Full Text :
- https://doi.org/10.1038/nsmb.3293