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Near-Infrared Light-Mediated Photodynamic Therapy Nanoplatform by the Electrostatic Assembly of Upconversion Nanoparticles with Graphitic Carbon Nitride Quantum Dots
- Source :
- Inorganic Chemistry; October 2016, Vol. 55 Issue: 20 p10267-10277, 11p
- Publication Year :
- 2016
-
Abstract
- Photodynamic therapy (PDT) is a promising antitumor treatment that is based on photosensitizers. This therapy kills cancer cells by generating reactive oxygen species (ROS) after irradiation with specific laser wavelengths. Being a potential photosensitizer, graphitic carbon nitride (g-C3N4) quantum dots (QDs) are noncytotoxic. Although the use of g-C3N4QDs is challenged by the limited tissue penetration of UV light, g-C3N4QDs display excellent ultraviolet (UV) light-triggered cytotoxicity. The g-C3N4QDs were synthesized using a solid-phase hydrothermal method. The well-distributed hydrophilic g-C3N4can be combined with NaYF4:Yb3+/Tm3+upconversion nanoparticles via the positive ligand poly(l-lysine) to produce the final nanocomposite, NaYF4:Yb/Tm-PLL@g-C3N4. Upconversion nanoparticles can transfer IR light into UV light and promote g-C3N4to release blue-to-green visible light to generate different images. Moreover, g-C3N4is a promising photosensitizer in PDT because g-C3N4can transfer oxygen into toxic ROS. The singlet oxygen formed by g-C3N4displays great potential for use in the treatment of cancer.
Details
- Language :
- English
- ISSN :
- 00201669 and 1520510X
- Volume :
- 55
- Issue :
- 20
- Database :
- Supplemental Index
- Journal :
- Inorganic Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs40080367
- Full Text :
- https://doi.org/10.1021/acs.inorgchem.6b01522