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Organ protection during aortic cross-clamping
- Source :
- Best Practice & Research Clinical Anaesthesiology; September 2016, Vol. 30 Issue: 3 p305-315, 11p
- Publication Year :
- 2016
-
Abstract
- Open surgical repair of an aortic aneurysm requires aortic cross-clamping, resulting in temporary ischemia of all organs and tissues supplied by the aorta distal to the clamp. Major complications of open aneurysm repair due to aortic cross-clamping include renal ischemia-reperfusion injury and postoperative colonic ischemia in case of supra- and infrarenal aortic aneurysm repair. Ischemia-reperfusion injury results in excessive production of reactive oxygen species and in oxidative stress, which can lead to multiple organ failure. Several perioperative protective strategies have been suggested to preserve renal function during aortic cross-clamping, such as pharmacotherapy and therapeutic hypothermia of the kidneys.
Details
- Language :
- English
- ISSN :
- 17533740 and 18781608
- Volume :
- 30
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Best Practice & Research Clinical Anaesthesiology
- Publication Type :
- Periodical
- Accession number :
- ejs39867077
- Full Text :
- https://doi.org/10.1016/j.bpa.2016.07.005