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In vivo fluorescence imaging of hepatocellular carcinoma xenograft using near-infrared labeled epidermal growth factor receptor (EGFR) peptide
- Source :
- Biomedical Optics Express; September 2016, Vol. 7 Issue: 9 p3163-3169, 7p
- Publication Year :
- 2016
-
Abstract
- Minimally-invasive surgery of hepatocellular carcinoma (HCC) can be limited by poor tumor visualization with white light. We demonstrate systemic administration of a Cy5.5-labeled peptide specific for epidermal growth factor receptor (EGFR) to target HCC in vivo in a mouse xenograft model. We attached a compact imaging module to the proximal end of a medical laparoscope to collect near-infrared fluorescence and reflectance images concurrently at 15 frames/sec. We measured a mean target-to-background ratio of 2.99 ± 0.22 from 13 surgically exposed subcutaneous human HCC tumors in vivo in 5 mice. This integrated imaging methodology is promising to guide laparoscopic resection of HCC.
Details
- Language :
- English
- ISSN :
- 21567085
- Volume :
- 7
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Biomedical Optics Express
- Publication Type :
- Periodical
- Accession number :
- ejs39735562