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Electrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation
- Source :
- Journal of the American College of Cardiology; July 1988, Vol. 12 Issue: 1 p19-24, 6p
- Publication Year :
- 1988
-
Abstract
- To assess the effects of early thrombolytic therapy on the incidence of clinical and induced ventricular arrhythmias in high risk postmyocardial infarction patients, 32 patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation were prospectively evaluated. Sixteen patients (Group A) received routine care because of contraindication to thrombolytic therapy or other factors and 16 (Group B) received either tissue plasminogen activator or streptokinase within 6 h of the onset of chest pain. The two groups were similar in left ventricular ejection fraction (mean ± SD, 28 ± 9% [Group A] versus 30 ± 8% [Group B]) and occurrence of spontaneous nonsustained ventricular tachycardia, new bundle branch block and congestive heart failure. Group B patients had higher peak creatine kinase MB levels (446 ± 336 versus 205 ± 120 IU; p = 0.017) and earlier time to peak creatine kinase values (13.4 ± 6.6 versus 19.1 ± 6.1 h; p = 0.006).
Details
- Language :
- English
- ISSN :
- 07351097 and 15583597
- Volume :
- 12
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of the American College of Cardiology
- Publication Type :
- Periodical
- Accession number :
- ejs39663929
- Full Text :
- https://doi.org/10.1016/0735-1097(88)90350-6