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Physalis alkekengiand Alhagi maurorumameliorate the side effect of cisplatin-induced nephrotoxicity

Physalis alkekengiand Alhagi maurorumameliorate the side effect of cisplatin-induced nephrotoxicity

Authors :
Changizi-Ashtiyani, S
Alizadeh, M
Najafi, H
Babaei, S
Khazaei, M
Jafari, M
Hossaini, N
Avan, A
Bastani, B
Source :
Cancer Gene Therapy; July 2016, Vol. 23 Issue: 7 p235-240, 6p
Publication Year :
2016

Abstract

Cisplatin is frequently being used for the treatment of different tumors, although the application of this agent is associated with nephrotoxicity. Here, we explored the antioxidant and anti-inflammatory activities of Physalis alkekengiand Alhagi maurorum; 400?mg?kg-1per day P. alkekengiand 100?mg?kg-1per day A. maurorumwere administered in rats, orally for 10 days after a single dose of 7 mg kg-1intraperitoneal cisplatin. The concentrations of creatinine, urea-nitrogen, and relative and absolute excretion of sodium/potassium were evaluated before/after therapy. Levels of malondialdehyde (MDA) and ferric-reducing antioxidant power (FRAP) were measured to assess the oxidative stress induced by cisplatin. Moreover, tissues sections were used for histological analyses and evaluation of the degree of tissue damage. Cisplatin increased serum levels of creatinine and urea-nitrogen, relative/absolute excretion of sodium/potassium, and MDA, whereas decreased FRAP level. Interestingly, P. alkekengior A. maurorumwere able to reduce the level of the renal function markers as well as the levels of sodium/potassium. This effect was more pronounced by P. alkekengi. Moreover, cisplatin induced pathological damage in kidney, whereas treatment with these agents improved this condition. Our findings demonstrate the potential therapeutic impact of P. alkekengiand A. maurorumfor improving cisplatin-induced nephrotoxicity, supporting further investigations on the novel potential clinical application of these agents for patients being treated with cisplatin to ameliorate cisplatin-induced nephrotoxicity.

Details

Language :
English
ISSN :
09291903 and 14765500
Volume :
23
Issue :
7
Database :
Supplemental Index
Journal :
Cancer Gene Therapy
Publication Type :
Periodical
Accession number :
ejs39597894
Full Text :
https://doi.org/10.1038/cgt.2016.24