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Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensislive vaccine strain
- Source :
- Innate Immunity; July 2016, Vol. 22 Issue: 5 p363-372, 10p
- Publication Year :
- 2016
-
Abstract
- The innate inflammatory response to Francisella tularensis(Ft) in macrophages is significantly governed by the expression of type I interferon (IFN). Previously, the proteolytic processing and maturation of pro-IL-1β protein was shown to depend upon type I IFN expression. We show in this report that paracrine type I IFN can profoundly enhance innate recognition and TLR-dependent transcriptional responses to Ftinfection upstream of its role in inflammasome regulation in both primary human monocyte-derived macrophages and primary murine peritoneal macrophages but not murine bone marrow-derived macrophages. This type I IFN-enhanced response is synergistic with TLR2 transcriptional responses, partially TLR2-independent, but strictly MyD88-dependent.
Details
- Language :
- English
- ISSN :
- 09680519 and 17534267
- Volume :
- 22
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Innate Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs39465769
- Full Text :
- https://doi.org/10.1177/1753425916650027