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Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

Authors :
Wang, Xiang
Feng, Jing
Xue, Yuan
Guan, Zeyuan
Zhang, Delin
Liu, Zhu
Gong, Zhou
Wang, Qiang
Huang, Jinbo
Tang, Chun
Zou, Tingting
Yin, Ping
Source :
Nature; June 2016, Vol. 534 Issue: 7608 p575-578, 4p
Publication Year :
2016

Abstract

The structure of the METTL3–METTL14 complex, which mediates N6-adenosine methylation of RNA, suggests that the METTL3 subunit is the catalytic core while METTL14 serves to bind RNA.

Details

Language :
English
ISSN :
00280836 and 14764687
Volume :
534
Issue :
7608
Database :
Supplemental Index
Journal :
Nature
Publication Type :
Periodical
Accession number :
ejs39430645
Full Text :
https://doi.org/10.1038/nature18298