Arene oxides and trans-dihydrodiols of quinoline

Authors :: Agarwal, S.K.
Boyd, D.R.
Porter, H.P.
Jennings, W.B.
Grossman, S.J.
Jerina, D.M.
Source :: Tetrahedron Letters; January 1986, Vol. 27 Issue: 36 p4253-4256, 4p
Publication Year :: 1986
Abstract: Arene oxides and trans-dihydrodiols at the 5,6- and 7,8-positions of quinoline have been synthesized. High stability of both arene oxides allowed identification of the 5,6-oxide as a liver microsomal metabolite of quinoline. Both arene oxides are converted to trans-dihydrodiols by microsamal epoxide hydrolase.