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Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
- Source :
- Nature; June 2016, Vol. 534 Issue: 7606 p272-276, 5p
- Publication Year :
- 2016
-
Abstract
- Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance.
Details
- Language :
- English
- ISSN :
- 00280836 and 14764687
- Volume :
- 534
- Issue :
- 7606
- Database :
- Supplemental Index
- Journal :
- Nature
- Publication Type :
- Periodical
- Accession number :
- ejs39337136
- Full Text :
- https://doi.org/10.1038/nature17963