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Sustained Modafinil Treatment Effects on Control-Related Gamma Oscillatory Power in Schizophrenia
- Source :
- Neuropsychopharmacology; April 2016, Vol. 41 Issue: 5 p1231-1240, 10p
- Publication Year :
- 2016
-
Abstract
- Control-related cognitive processes such as rule selection and maintenance are associated with cortical oscillations in the gamma range, and modulated by catecholamine neurotransmission. Control-related gamma power is impaired in schizophrenia, and an understudied treatment target. It remains unknown whether pro-catecholamine pharmacological agents augment control-related gamma oscillations in schizophrenia. We tested the effects of 4-week fixed-dose daily adjunctive modafinil (MOD) 200 mg, in a randomized double-blind, placebo-controlled, parallel-groups design. Twenty-seven stable schizophrenia patients performed a cognitive control task during EEG, at baseline and after 4 weeks of treatment. EEG data underwent time-frequency decomposition with Morlet wavelets to determine power of 4–80 Hz oscillations. The modafinil group (n=14), relative to placebo group (n=13), exhibited enhanced oscillatory power associated with high-control rule selection in the gamma range after treatment, with additional effects during rule maintenance in gamma and sub-gamma ranges. MOD-treated patients who exhibited improved task performance with treatment also showed greater treatment-related delay period gamma compared with MOD-treated patients without improved performance. This is the first evidence in schizophrenia of augmentation of cognition-related gamma oscillations by an FDA-approved agent with therapeutic potential. Gamma oscillations represent a novel treatment target in this disorder, and modulation of catecholamine signaling may represent a viable strategy at this target.
Details
- Language :
- English
- ISSN :
- 0893133X and 1740634X
- Volume :
- 41
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Neuropsychopharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs38311766
- Full Text :
- https://doi.org/10.1038/npp.2015.271