Steroids IX

The synthesis of thiazolo[d-3,2]-5α-cholest-2-ene, and thiazolo[d-3,2]-17α-methyl-5α-androst-2-en-17β-ol, and eight of their 2′-derivatives is reported. These derivatives include the 2′-methyl, 2′-amino, 2′-allylamino, and 2′-phenylamino substituted thiazolosteroids. Preliminary data indicate that 2′-methylthiazolo[d-3,2]-17α methyl-5α-androst-2-en-17β-ol is a good anabolic agent.