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Fluorinated Phenytoin Anticonvulsant Analogs
- Source :
- Journal of Pharmaceutical Sciences; January 1979, Vol. 68 Issue: 1 p115-117, 3p
- Publication Year :
- 1979
-
Abstract
- Six ring-fluorinated phenytoin analogs were synthesized, and their anticonvulsant activity in the maximal electroshock seizure and subcutaneous pentylenetetrazol assays was determined. 5-(4-Fluoro- phenyl)-5-phenylhydantoin, 5-(3-fluorophenyl)-5-phenylhydantoin, and 5,5-bis(4-fluorophenyl)hydantoin were active in the maximal electroshock seizure assay. The compounds were much less potent than phenytoin but showed an extremely long duration of action.
Details
- Language :
- English
- ISSN :
- 00223549 and 15206017
- Volume :
- 68
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Pharmaceutical Sciences
- Publication Type :
- Periodical
- Accession number :
- ejs37976291
- Full Text :
- https://doi.org/10.1002/jps.2600680141