Derivatives of 17a-Aza-D-homo-5-androsten-3β-ol

The synthesis of several types of N-substituted derivatives of 17a-aza-D-homo-5-androsten-3β-ol as potential antimicrobial agents is reported. Methyl and propyl groups were added by reductive alkylation, and β-dialkylaminoethyl and γ-dialkylaminopropyl groups were introduced by the reaction of dimethylamine or piperidine with the appropriate 17a-(ω-chloroacyl) derivative of VI. None of these derivatives exhibited significant antibacterial or antifungal activity.