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Activator Protein 1 Activation following Hypoosmotic Stress in HepG2 Cells Is Actin Cytoskeleton Dependent

Authors :
Kim, Robin D.
Darling, Chad E.
Roth, Timothy P.
Ricciardi, Rocco
Chari, Ravi S.
Source :
Journal of Surgical Research; October 2001, Vol. 100 Issue: 2 p176-182, 7p
Publication Year :
2001

Abstract

Background.Following hypoosmotic stress-induced cell volume change, the actin cytoskeleton reorganizes itself. The role of this reorganization in the activation of the phosphatidylinositol 3-OH-kinase/protein kinase B/activator protein 1 (PI-3-K/PKB/AP-1) proliferative signaling cascade is unknown. Focal adhesion kinase (FAK) participates in the cytoskeleton-based activation of PI-3-K. We hypothesized that hypoosmotic stress-induced activation of PKB and AP-1 in HepG2 cells is dependent on an intact actin cytoskeleton and subsequent FAK phosphorylation.

Details

Language :
English
ISSN :
00224804 and 10958673
Volume :
100
Issue :
2
Database :
Supplemental Index
Journal :
Journal of Surgical Research
Publication Type :
Periodical
Accession number :
ejs378253
Full Text :
https://doi.org/10.1006/jsre.2001.6225