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Activator Protein 1 Activation following Hypoosmotic Stress in HepG2 Cells Is Actin Cytoskeleton Dependent
- Source :
- Journal of Surgical Research; October 2001, Vol. 100 Issue: 2 p176-182, 7p
- Publication Year :
- 2001
-
Abstract
- Background.Following hypoosmotic stress-induced cell volume change, the actin cytoskeleton reorganizes itself. The role of this reorganization in the activation of the phosphatidylinositol 3-OH-kinase/protein kinase B/activator protein 1 (PI-3-K/PKB/AP-1) proliferative signaling cascade is unknown. Focal adhesion kinase (FAK) participates in the cytoskeleton-based activation of PI-3-K. We hypothesized that hypoosmotic stress-induced activation of PKB and AP-1 in HepG2 cells is dependent on an intact actin cytoskeleton and subsequent FAK phosphorylation.
Details
- Language :
- English
- ISSN :
- 00224804 and 10958673
- Volume :
- 100
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Journal of Surgical Research
- Publication Type :
- Periodical
- Accession number :
- ejs378253
- Full Text :
- https://doi.org/10.1006/jsre.2001.6225