Use of Extraction Generator for Preparing a 99mTc Radiopharmaceutical

Data are reported on the use of extraction generator for preparing high-purity 99mTc from 99Mo, and the quality of the solution of 99mTc is studied. The radiolysis products of the extractant, methyl ethyl ketone (MEK), are examined; the major products are MEK dimers, and their content under operating conditions does not exceed 0.005%. A high degree of removal of both inorganic and organic impurities from the 99mTc eluate obtained from the extraction generator (Radium Institute) is achieved. This ensures a high quality of radiopharmaceuticals prepared from this 99mTc solution. The 99mTc solution prepared with the extraction generator surpasses in quality the similar solution prepared with the sorption generator. When a centrifugal extractor is used for separating 99Mo and 99mTc, the concentration of MEK in the solution of 99mTc does not exceed 0.04 mg ml-1.