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Recurrent inactivating RASA2 mutations in melanoma
- Source :
- Nature Genetics; December 2015, Vol. 47 Issue: 12 p1408-1410, 3p
- Publication Year :
- 2015
-
Abstract
- Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Volume :
- 47
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Nature Genetics
- Publication Type :
- Periodical
- Accession number :
- ejs37364587
- Full Text :
- https://doi.org/10.1038/ng.3427