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Hydatidiform moles and the long-term risk of breast cancer (Sweden)
- Source :
- Cancer Causes and Control; February 2000, Vol. 11 Issue: 2 p117-120, 4p
- Publication Year :
- 2000
-
Abstract
- Objectives: The etiology of breast cancer is only partially understood. Based on the findings that pregnancies reduce breast cancer risk, a possible inverse association between exposure to the placental hormone human chorionic gonadotropin (hCG) and the risk of breast cancer has been suggested. Hydatidiform mole, a gestational trophoblastic disease, is associated with a high expression of hCG. We performed a population-based cohort study in which women with a history of hydatidiform mole were followed up for future cancer outcomes. Methods: All 3371 women with a notification of hydatidiform mole in the Swedish Cancer Registry between 1958 and 1993 were followed up for future cancer outcomes by record linkages within the registry. Results: In a total of 57,075 person-years of follow-up, 59 women had a diagnosis of breast cancer during follow-up, yielding an overall standardized incidence ratio of 1.3 (95% CI 1.0–1.7). Conclusion: This finding is not consistent with the hypothesis of a protective effect of hCG exposure on breast cancer risk, but rather suggests an adverse association.
Details
- Language :
- English
- ISSN :
- 09575243 and 15737225
- Volume :
- 11
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Cancer Causes and Control
- Publication Type :
- Periodical
- Accession number :
- ejs36933229
- Full Text :
- https://doi.org/10.1023/A:1008915217389