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Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas
- Source :
- Autophagy; December 2013, Vol. 9 Issue: 12 p2163-2165, 3p
- Publication Year :
- 2013
-
Abstract
- Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advanced cancer cells survive stressful conditions such as chemotherapy. Here we review our recent findings describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. These results propose a new and promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome.
Details
- Language :
- English
- ISSN :
- 15548627 and 15548635
- Volume :
- 9
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Autophagy
- Publication Type :
- Periodical
- Accession number :
- ejs36430507
- Full Text :
- https://doi.org/10.4161/auto.26450