Back to Search Start Over

Structural Basis for Understanding Structure−Activity Relationships for the Glutamate Binding Site of the NMDA Receptor

Structural Basis for Understanding Structure−Activity Relationships for the Glutamate Binding Site of the NMDA Receptor

Authors :
Tikhonova, I. G.
Baskin, I. I.
Palyulin, V. A.
Zefirov, N. S.
Bachurin, S. O.
Source :
Journal of Medicinal Chemistry; August 2002, Vol. 45 Issue: 18 p3836-3843, 8p
Publication Year :
2002

Abstract

We present new homology-based models of the glutamate binding site (in closed and open forms) of the NMDA receptor NR2B subunit derived from X-ray structures of the water soluble AMPA sensitive glutamate receptor. The models were used for revealing binding modes of agonists and competitive antagonists, as well as for rationalizing known experimental facts concerning structure−activity relationships:  (i) the switching between the agonist and the antagonist modes of action upon lengthening the chain between the distal acidic group and the amino acid moiety, (ii) the preference for the methyl group attached to the α-amino group of ligands, (iii) the preference for the <SCP>d</SCP>-configuration of agonists and antagonists, and (iv) the existence of “superacidic” agonists.

Details

Language :
English
ISSN :
00222623 and 15204804
Volume :
45
Issue :
18
Database :
Supplemental Index
Journal :
Journal of Medicinal Chemistry
Publication Type :
Periodical
Accession number :
ejs3640791
Full Text :
https://doi.org/10.1021/jm011091t