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Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging
- Source :
- Cell Reports; July 2015, Vol. 12 Issue: 2 p163-171, 9p
- Publication Year :
- 2015
-
Abstract
- Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here, we demonstrate an increase in the ratio of inhibitory T follicular regulatory (TFR) cells to stimulatory T follicular helper (TFH) cells in aged mice. Aged TFH and TFR cells are phenotypically distinct from those in young mice, exhibiting increased programmed cell death protein-1 expression but decreased ICOS expression. Aged TFH cells exhibit defective antigen-specific responses, and programmed cell death protein-ligand 1 blockade can partially rescue TFH cell function. In contrast, young and aged TFR cells have similar suppressive capacity on a per-cell basis in vitro and in vivo. Together, these studies reveal mechanisms contributing to defective humoral immunity in aging: an increase in suppressive TFR cells combined with impaired function of aged TFH cells results in reduced T-cell-dependent antibody responses in aged mice.
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 12
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs36344806
- Full Text :
- https://doi.org/10.1016/j.celrep.2015.06.015