Immunohistochemical evaluation of neoangiogenesis in canine mast cell tumours

Authors :: Kandefer-Gola, Małgorzata
Madej, Janusz A.
Dzimira, Stanisław
Janus, Izabela
Nowak, Marcin
Ciaputa, Rafał
Source :: Bulletin of the Veterinary Institute in Pulawy; June 2015, Vol. 59 Issue: 2 p247-253, 7p
Publication Year :: 2015
Abstract: The aim of the study was to assess the microvessel density based on the analysis of the expression of the CD31, VEGF, and LIMS-1 proteins in canine mast cell tumours. The study was conducted on 60 mastocytomas; 16 cases were classified as the grade I, 26 as the grade II, and 18 as the grade III. Statistical analysis showed a positive correlation only between the grade of the tumour and the expression of LIMS-1. In conclusion, LIMS-1 could be successfully used as a prognostic endothelial cell marker in mast cell tumour. CD31 may be a useful marker, but further examinations are necessary. VEGF is not recommended