Effects of changes in intracellular iron pool on AlkB-dependent and AlkB-independent mechanisms protecting E.colicells against mutagenic action of alkylating agent

Authors :: Sikora, Anna
Maciejewska, Agnieszka M.
Poznański, Jarosław
Pilżys, Tomasz
Marcinkowski, Michał
Dylewska, Małgorzata
Piwowarski, Jan
Jakubczak, Wioletta
Pawlak, Katarzyna
Grzesiuk, Elżbieta
Source :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; August 2015, Vol. 778 Issue: 1 p52-60, 9p
Publication Year :: 2015
Abstract: •The intracellular free iron in E.coli hemHappear to be double that in wt strain.•Increased Fe(II) and AlkB concentrations result in decreased MMS-induced mutations.•Dealkylation of dNTPs takes place in the presence of Fe(II) and not requires AlkB.

Language :: English
ISSN :: 13861964
Volume :: 778
Issue :: 1
Database :: Supplemental Index
Journal :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publication Type :: Periodical
Accession number :: ejs36267374
Full Text :: https://doi.org/10.1016/j.mrfmmm.2015.05.009

Full Text Access

Tools