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Molecular structure of deoxycytidyl-3'- ethylphosphonate (RP) 5'-deoxyguanidine, d[Cp(CH3)G]. A neutral dinucleotide with Watson-Crick base pairing and a right handed helical twist
- Source :
- Nucleic Acids Research; May 1990, Vol. 18 Issue: 9 p2759-2759, 1p
- Publication Year :
- 1990
-
Abstract
- The crystal structure of d[Cp(CH<inf>3</inf>)G] has been determined as part of a project to study the mechanism of the B-Z transition in DNA. The asymmetric unit contains two dinucleotldes and the equivalent of 7.5 water molecules, partially disordered over 12 definable positions. The two symmetry-independent dinucleotides form a duplex with Watson-Crick basepairing and a right-handed helical sense. Comparison with previously determined structures of the B and A conformation showed that this duplex is closer to B than to A but significantly different from B. It corresponds to a stretched out helix with a 4 A rise per base pair and a helical twist of 32°. This structure may serve as a model for the bending of DNA in certain situations. The configuration at the methyl phosphonate is RP, and a mechanism, based on this assignment, is presented for the B–Z transition in DNA.
Details
- Language :
- English
- ISSN :
- 03051048 and 13624962
- Volume :
- 18
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Nucleic Acids Research
- Publication Type :
- Periodical
- Accession number :
- ejs35891535
- Full Text :
- https://doi.org/10.1093/nar/18.9.2759