UNC-87 isoforms, Caenorhabditis eleganscalponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility

Two UNC-87 isoforms with seven calponin-like repeats are expressed widely in muscle and nonmuscle cells in Caenorhabditis elegans. They bind to actin and myosin and inhibit actomyosin motility in vitro. unc-87 mutation enhances contraction of nonstriated muscle in vivo, suggesting that UNC-87 isoforms are negative regulators of actomyosin contractility.