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Analysis of Mosquito-Borne Flavivirus Superinfection in Culex tritaeniorhynchus (Diptera: Culicidae) Cells Persistently Infected with Culex Flavivirus (Flaviviridae)
- Source :
- Journal of Medical Entomology; March 2015, Vol. 52 Issue: 2 p222-222, 1p
- Publication Year :
- 2015
-
Abstract
- Superinfection exclusion is generally defined as a phenomenon in which a pre-existing viral infection prevents a secondary viral infection; this has also been observed in infections with mosquito-borne viruses. In this study, we examined the superinfection exclusion of the vertebrate-infecting flaviviruses, Japanese encephalitis virus (JEV) and dengue virus (DENV), by stable and persistent infection with an insect-specific flavivirus, Culex flavivirus (CxFV), in a Culex tritaeniorhynchus</it> Giles cell line (CTR cells). Our experimental system was designed based on the premise that wild Cx. tritaeniorhynchus</it> mosquitoes naturally infected with CxFV are superinfected with JEV by feeding on JEV-infected animals. As a result, we found no evidence of the superinfection exclusion of both JEV and DENV by pre-existing CxFV infection at the cellular level. However, JEV superinfection induced severe cytopathic effects on persistently CxFV-infected CTR cells. These observations imply the possibility that JEV superinfection in CxFV-infected Cx. tritaeniorhynchus</it> mosquitoes has an adverse effect on their fitness.
Details
- Language :
- English
- ISSN :
- 00222585 and 19382928
- Volume :
- 52
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Journal of Medical Entomology
- Publication Type :
- Periodical
- Accession number :
- ejs35609827
- Full Text :
- https://doi.org/10.1093/jme/tju059