SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation

Authors :: Xie, Yuexia
Tu, Wenzhi
Zhang, Jianghong
He, Mingyuan
Ye, Shuang
Dong, Chen
Shao, Chunlin
Source :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; February 2015, Vol. 772 Issue: 1 p23-29, 7p
Publication Year :: 2015
Abstract: •γ-Irradiation induced bystander effects between hepatoma cells and hepatocyte cells.•SirT1 played a protective role in regulating this bystander effect.•SirT1 contributed to the protective effects viaelimination the accumulation of ROS.•The activity of c-Myc is critical for maintaining the protective role of SirT1.

Language :: English
ISSN :: 13861964
Volume :: 772
Issue :: 1
Database :: Supplemental Index
Journal :: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publication Type :: Periodical
Accession number :: ejs34575073
Full Text :: https://doi.org/10.1016/j.mrfmmm.2014.12.010

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