Role of histamine and diamine oxidase enzyme in Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic inflammatory disease of the Central Nervous System (CNS) which is characterized by demyelination and axonal loss. It has been shown that Diamine Oxidase (DAO) enzyme degrades histamine. Histamine has a role in increasing permeability of Blood–Brain Barrier (BBB) that leads to immune cells infiltration of CNS and has a proinflammatory effect via H1R receptor. The objective of the project is to measure serum levels of histamine and DAO enzyme of patients with Relapsing Remitting Multiple Sclerosis (RRMS) in comparison with healthy control subjects.