Sublingual misoprostol versus intramuscular oxytocin for prevention of post-partum haemorrhage in Uganda: a randomised, controlled, non-inferiority trial

Postpartum haemorrhage is a leading cause of maternal death in sub-Saharan Africa. Although WHO recommends use of oxytocin for prevention of postpartum haemorrhage, misoprostol is increasingly used owing to advantages in shelf life, ease of use, storage, and potential for sublingual administration. We assessed the comparative efficacy of oxytocin and sublingual misoprostol for prevention of postpartum haemorrhage during labour.