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Effect of nodakenin on atopic dermatitis-like skin lesions
- Source :
- Bioscience, Biotechnology, and Biochemistry; September 2014, Vol. 78 Issue: 9 p1568-1571, 4p
- Publication Year :
- 2014
-
Abstract
- Nodakenin, derived from the roots of Angelica gigas Nakai, is an important natural resource and medicinal material with anti-allergic and anti- inflammatory activities. We have previously shown that nodakenin inhibits IgE/Ag-induced degranulation in mast cells. In this study, we investigated the inhibitory effect of nodakenin on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)- like skin lesions in ICR mice. Scratching behavior, skin severity score, blood IgE level, and skin thickness were improved in DNCB-induced AD-like ICR mice. Our results showed that nodakenin suppressed the increase of AD-like skin lesions in ICR mice. These results suggest that nodakenin may be a potential therapeutic resource for AD as well as an adjunctive agent to control itching associated with AD.
Details
- Language :
- English
- ISSN :
- 09168451 and 13476947
- Volume :
- 78
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Bioscience, Biotechnology, and Biochemistry
- Publication Type :
- Periodical
- Accession number :
- ejs33794859
- Full Text :
- https://doi.org/10.1080/09168451.2014.923296