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Resveratrol as a Gene Regulator in the Vasculature
- Source :
- Current Pharmaceutical Biotechnology; 2014, Vol. 15 Issue: 4 p401-408, 8p
- Publication Year :
- 2014
-
Abstract
- Resveratrol (3,5,4'-trihydroxy-trans-stilbene) possesses multiple protective properties in the vasculature, including anti-oxidative and anti-inflammatory effects and improvement of endothelial function. A substantial part of these effects is attributable to gene expression changes induced by the compound. Resveratrol can activate the NAD-dependent deacetylase sirtuin 1 (SIRT1), leading to deacetylation of SIRT1 target molecules such as NF-kB and forkhead box O (FOXO) transcription factors. The inhibition of NF-kB by resveratrol reduces the expression of inflammation mediators. FOXO factors are implicated in the upregulation of antioxidant enzymes and the endothelial-type nitric oxide synthase. In addition, resveratrol upregulates a number of antioxidant enzymes by activating nuclear factor-E2-related factor-2 (Nrf2) and downregulates NADPH oxidases through yet known mechanisms.
Details
- Language :
- English
- ISSN :
- 13892010
- Volume :
- 15
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Current Pharmaceutical Biotechnology
- Publication Type :
- Periodical
- Accession number :
- ejs33680540