Primary Familial Amyloidosis of the Cornea

The stromal deposits of a failed corneal graft from a patient with primary familial amyloidosis of the cornea stained positively with Congo red and showed green birefringence with polarized light. These deposits contained protein AP but not protein AA, immunoglobulins, light chains, or prealbumin. The amyloid deposits of primary familial amyloidosis of the cornea differ from those in lattice corneal dystrophy which contain both protein AA and protein AP.