In vitroanti-diabetic effect and chemical component analysis of 29 essential oils products

Twenty-nine commercial essential oil (EO) products that were purchased from the Taiwan market, including three different company-made Melissa officinalisessential oils, were assayed on their glucose consumption activity and lipid accumulation activity on 3T3-L1 adipocytes. The EOs of M. officinaliswere significantly active in both model assays. By contrast, EOs of peppermint, lavender, bergamot, cypress, niaouli nerolidol, geranium-rose, and revensara did not increase glucose consumption activity from media, but displayed inhibited lipid accumulation activity (65–90% of lipid accumulation vs. the control 100%). Because of the promising activity of M. officinalisEOs, three different products were collected and compared for their gas chromatography chemical profiles and bioactivity. The Western blot data suggest that the key factors of the adenosine monophosphate-activated protein kinase/acetyl-CoA carboxylase pathway can be mediated by M. officinalisEOs. Together with biodata, gas chromatography–mass spectrometry profiles suggested mixtures of citrals and minor compounds of M. officinalisEOs may play an important role on effect of antidiabetes.