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New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent
- Source :
- Antimicrobial Agents and Chemotherapy; April 2014, Vol. 58 Issue: 7 p4242-4245, 4p
- Publication Year :
- 2014
-
Abstract
- ABSTRACTCBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 58
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs33044188
- Full Text :
- https://doi.org/10.1128/AAC.02600-14